Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression
AUTOR(ES)
Kim, Chong-Hyun
FONTE
The National Academy of Sciences
RESUMO
The interaction of PDZ domain-containing proteins with the C termini of α-amino-3-hydroxy-5-methylisoxazolepropionate (AMPA) receptors has been suggested to be important in the regulation of receptor targeting to excitatory synapses. Recent studies have shown that the rapid internalization of AMPA receptors at synapses may mediate, at least in part, the expression of long-term depression (LTD). We have previously shown that phosphorylation of Ser-880 on the AMPA receptor GluR2 subunit differentially regulated the interaction of GluR2 with the PDZ domain-containing proteins GRIP1 and PICK1. Here, we show that induction of LTD in hippocampal slices increases phosphorylation of Ser-880 within the GluR2 C-terminal PDZ ligand, suggesting that the modulation of GluR2 interaction with GRIP1 and PICK1 may regulate AMPA receptor internalization during LTD. Moreover, postsynaptic intracellular perfusion of GluR2 C-terminal peptides that disrupt GluR2 interaction with PICK1 inhibit the expression of hippocampal LTD. These results suggest that the interaction of GluR2 with PICK1 may play a regulatory role in the expression of LTD in the hippocampus.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=58797Documentos Relacionados
- Disruption of AMPA receptor GluR2 clusters following long-term depression induction in cerebellar Purkinje neurons
- Hypothermia rescues hippocampal CA1 neurons and attenuates down-regulation of the AMPA receptor GluR2 subunit after forebrain ischemia
- Hippocampal long-term depression and long-term potentiation encode different aspects of novelty acquisition
- Protein phosphatase 2A inhibition induces cerebellar long-term depression and declustering of synaptic AMPA receptor
- Novelty acquisition is associated with induction of hippocampal long-term depression