Interactions between Depression and Facilitation within Neural Networks: Updating the Dual-Process Theory of Plasticity

AUTOR(ES)

Prescott, Steven A.

FONTE

Cold Spring Harbor Laboratory Press

RESUMO

Repetitive stimulation often results in habituation of the elicited response. However, if the stimulus is sufficiently strong, habituation may be preceded by transient sensitization or even replaced by enduring sensitization. In 1970, Groves and Thompson formulated the dual-process theory of plasticity to explain these characteristic behavioral changes on the basis of competition between decremental plasticity (depression) and incremental plasticity (facilitation) occurring within the neural network. Data from both vertebrate and invertebrate systems are reviewed and indicate that the effects of depression and facilitation are not exclusively additive but, rather, that those processes interact in a complex manner. Serial ordering of induction of learning, in which a depressing locus precedes the modulatory system responsible for inducing facilitation, causes the facilitation to wane. The parallel and/or serial expression of depression and waning facilitation within the stimulus–response pathway culminates in the behavioral changes that characterize dual-process learning. A mathematical model is presented to formally express and extend understanding of the interactions between depression and facilitation.

Documentos Relacionados

• Interactions of neural networks: models for distraction and concentration.
• Oscillations and chaos in neural networks: an exactly solvable model.
• Noise in neural networks: thresholds, hysteresis, and neuromodulation of signal-to-noise.
• Spatial facilitation and depression within one motor nerve terminal of frogs.
• Uniting pattern and process in plant–animal mutualistic networks: a review