Interferência da dexametasona no ciclo pulmonar da infecção por Strongyloides venezuelensis em ratos Wistar / Interference of dexamethasone in pulmonary cycle of infection by Strongyloides venezuelensis in Wistar rats

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

The aim of this study was investigate the interference of dexamethasone treatment in the pulmonary cycle of Strongyloides venezuelensis infection in rats. The immunomodulatory effects on the inflammatory process generated by the passage of the larvae into pulmonary parenchyma during their migration were analyzed. Three principal effects were found: 1) Increased alveolar hemorrhagic inflammation provoked by the passage of larvae into the alveolar spaces; 2) Significant decrease of eosinophil and mast cell migration to the axial septum of the lungs and 3) Impaired eosinophil migration to the parasite foci and deficient formation of the reticular fiber network, interfering with the granuloma organization. This study demonstrated that the use of drugs with immunomodulatory actions, such as dexamethasone, in addition to interfere with the morbidity from the pulmonary cycle of S. venezuelensis infection, can contribute to reveal the mechanisms involved in its pathogenesis.

ASSUNTO(S)

strongyloides venezuelensis parasitas dexametasona strongyloides venezuelensis dexamethasone parasites lung pulmão

ACESSO AO ARTIGO

Documentos Relacionados