Interferon induces pulmonary cysts in A2G mice.
AUTOR(ES)
Woodrow, D
RESUMO
Suckling A2G mice were treated for the first week of life with either partially purified or electrophoretically pure mouse alpha/beta interferon. All mice subsequently developed multiple large pulmonary cysts. The lesions were never found in interferon-treated Swiss mice and only very infrequently in interferon-treated BALB/c or F1 Swiss/A2G mice. These observations show that a brief exposure of suckling A2G mice to alpha/beta interferon can result in a severe disease that is determined by the mouse genotype.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=392268Documentos Relacionados
- Effects of 2',3'-dideoxyinosine on Toxoplasma gondii cysts in mice.
- Effect of Immunosuppression on the Genetic Resistance of A2G Mice to Neurovirulent Influenza Virus
- Effect of immunosuppression on the genetic resistance of A2G mice to neurovirulent influenza virus.
- Mx1-Based Resistance to Thogoto Virus in A2G Mice Is Bypassed in Tick-Mediated Virus Delivery
- Recombinant murine gamma interferon induces enhanced resistance to Listeria monocytogenes infection in neonatal mice.