Interleucina-6 como marcador de mortalidade na fase precoce da sepse grave e choque séptico.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

Sepsis and multiple organ failure are the most important causes of death in critically ill patients. Despite the groundbreaking therapeutic and diagnostic resources, mortality rates are still high. A number of inflammatory mediators have been evaluated due to their role as potential markers of the presence and severity of inflammatory response and organ dysfunction. Objective: The aim of the present study was to evaluate serum levels of IL-6 in the early phase of severe sepsis and septic shock, correlating them with the course of organ failure and mortality. Method: Serum levels of IL-6 were obtained in 33 patients with severe sepsis or septic shock and correlated with the course of the disease and mortality in subgroups presenting IL-6 serum levels higher and lower than 100 pg/mL. Results: Mortality rate was 31% in the subgroup presenting IL-6 level lower than 100 pg/mL at admission. Regarding the subgroup presenting levels higher than 100 pg/mL, mortality rate was 69% (RR 2.31; 95% CI 1.08-4.94; p = 0.038). Conclusion: These findings suggest that the evaluation of IL-6 serum level is very useful in the early phase of the disease in order to identify the high-risk patients.

ASSUNTO(S)

sepse grave septic shock marcador biológico biological marker, interleukin- 6 interleucina-6 choque séptico severe sepsis mortality mortalidade pediatria

ACESSO AO ARTIGO

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