Interleukin 2-dependent release of interleukin 3 activity by T4+ human T-cell clones.

AUTOR(ES)

Ythier, A A

RESUMO

We have isolated and studied two alloreactive, T4+, human lymphocyte clones that release interleukin 2 (IL-2) and interleukin 3 (IL-3) bioactivities upon stimulation with IL-2, alloantigen, or Sepharose-conjugated antibodies directed against the T3 protein. Anti-IL-2 receptor monoclonal antibodies block IL-2-, alloantigen-, or anti-T3-stimulated IL-3 release. Hence, release of IL-3 activity in each circumstance is rigorously dependent upon activation of the IL-2 receptor. Even low, nonmitogenic concentrations of recombinant IL-2 stimulated IL-3 release.

Documentos Relacionados

• T-cell activation by autologous human T-cell leukemia virus type I-infected T-cell clones.
• Dengue virus-specific, human CD4+ CD8- cytotoxic T-cell clones: multiple patterns of virus cross-reactivity recognized by NS3-specific T-cell clones.
• Abelson virus transformation of an interleukin 2-dependent antigen-specific T-cell line.
• Identification of T-cell epitopes on E2 protein of rubella virus, as recognized by human T-cell lines and clones.
• Patterns of cytokine production by mycobacterium-reactive human T-cell clones.