Interleukin-6 production by human monocytes stimulated with Cryptococcus neoformans components.

AUTOR(ES)

Delfino, D

RESUMO

In order to ascertain if Cryptococcus neoformans components can induce interleukin-6 (IL-6) production, we stimulated human whole blood with purified capsular products. Their potencies in stimulating IL-6 release were mannoproteins > galactoxylomannan = glucuronoxylomannan > alpha(1-3)glucan. IL-6 production was tumor necrosis factor alpha independent and required the presence of monocytes and plasma. Since IL-6 can stimulate replication of the human immunodeficiency virus in monocytic cells, these findings may be clinically relevant.

Documentos Relacionados

• Production of interleukin-1 but not tumor necrosis factor by human monocytes stimulated with pneumococcal cell surface components.
• Endogenous pyrogen production by human blood monocytes stimulated by staphylococcal cell wall components.
• Purified capsular polysaccharide of Cryptococcus neoformans induces interleukin-10 secretion by human monocytes.
• Early Induction of Interleukin-12 by Human Monocytes Exposed to Cryptococcus neoformans Mannoproteins
• Posttranscriptional Suppression of Interleukin-6 Production by Human Cytomegalovirus