Interleukin 9: A candidate gene for asthma
AUTOR(ES)
Nicolaides, Nicholas C.
FONTE
The National Academy of Sciences of the USA
RESUMO
Asthma is a complex heritable inflammatory disorder of the airways associated with clinical signs of atopy and bronchial hyperresponsiveness. Recent studies localized a major gene for asthma to chromosome 5q31-q33 in humans. Thus, this segment of the genome represents a candidate region for genes that determine susceptibility to bronchial hyperresponsiveness and atopy in animal models. Homologs of candidate genes on human chromosome 5q31-q33 are found in four regions in the mouse genome, two on chromosome 18, and one each on chromosomes 11 and 13. We assessed bronchial responsiveness as a quantitative trait in mice and found it linked to chromosome 13. Interleukin 9 (IL-9) is located in the linked region and was analyzed as a gene candidate. The expression of IL-9 was markedly reduced in bronchial hyporesponsive mice, and the level of expression was determined by sequences within the qualitative trait locus (QTL). These data suggest a role for IL-9 in the complex pathogenesis of bronchial hyperresponsiveness as a risk factor for asthma.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=24282Documentos Relacionados
- Th2 cytokines and asthma — Interleukin-9 as a therapeutic target for asthma
- Arginase: marker, effector, or candidate gene for asthma?
- Candidate gene analysis of ocular toxoplasmosis in Brazil: evidence for a role for toll-like receptor 9 (TLR9)
- The gene encoding interleukin-13: a susceptibility locus for asthma and related traits
- Evidence to exclude SOX9 as a candidate gene for XY sex reversal without skeletal malformation.
