Interplay between Plasmid Partition and Postsegregational Killing Systems

AUTOR(ES)

Brendler, Therese

FONTE

American Society for Microbiology

RESUMO

Active partition systems and postsegregational killing (PSK) systems are present together in naturally occurring low-copy-number plasmids. Theory suggests that PSK may act as the ultimate determinant of plasmid retention, whereas the partition system may minimize the growth penalty to the host, resulting in a near-ideal symbiosis when the systems combine. Here, we prove the validity of this principle for a specific case involving the P1par system and the mvp PSK system.

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