Intracellular immunoglobulin distribution of bone marrow plasma cells as a diagnostic aid for primary amyloidosis.

AUTOR(ES)

Thielemans, C

RESUMO

In order to classify the underlying disorder in four patients with biopsy-proven amyloidosis without overt monoclonal gammopathy, the cytoplasmic immunoglobulin (Ig) distribution of bone marrow plasma cells was evaluated using direct immunofluorescence microscopy. This procedure revealed the presence of a monoclonal proliferation of light chain containing plasma cells, and thus led to the diagnosis of immunoglobulin-related amyloidosis.

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