Intracellular Penetration and Activity of Gemifloxacin in Human Polymorphonuclear Leukocytes
AUTOR(ES)
García, Isabel
FONTE
American Society for Microbiology
RESUMO
The intracellular penetration and activity of gemifloxacin in human polymorphonuclear leukocytes (PMN) were evaluated. Gemifloxacin reached intracellular concentrations eight times higher than extracellular concentrations. The uptake was rapid, reversible, and nonsaturable and was affected by environmental temperature, cell viability, and membrane stimuli. At therapeutic extracellular concentrations, gemifloxacin showed intracellular activity against Staphylococcus aureus.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=101631Documentos Relacionados
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