IridÃides glicosilados das raÃzes de Lippia alba (Mill.) N. E. Brown

AUTOR(ES)

Josà Guedes de Sena Filho

DATA DE PUBLICAÇÃO

2007

RESUMO

The present work focuses the isolation, characterization and bioactivity, of iridoids glucosides from the roots of Lippia alba (Mill.) N. E. Brown, as well as the chemotype evaluation. Itâs a notable plant in the traditional medicine in our country, where it is known as âerva-cidreiraâ, âchÃ-do-abuleiroâ, âerva-cidreira-de-arbustoâ, âalecrimselvagemâ, âcidreira-bravaâ and others. It was isolated and characterized 3 iridoids: theviridoside, mussaenoside e gardoside from the roots of such plant. The fists two are being described in the literature, for the first time in the roots, the third one for the first time in the Lippia genus. The chemotype was defined as âcitralÃferaâ due to major compound found citral (19.08%), therefore the presence of cis-verbenol in high concentration (9.73%) could be associated in a new derivate of this chemotype. In addition, the analyses of the minor terpenes from the roots (GC/MS) afford the existence of: limonene, carvone, 9-hexadecenoic acid methyl ester, and patchoulene, without literature data base. The Aqueous Extract (EAQ) did not present antimicrobial activity. The LD50 was 1156 mg/kg, moreover were observed fecal excretion, abdomens contortions and others. The ethyl acetate (EEA) and methanolic extract (EME) were modest against the microorganism tested: Staphylococcus aureus (ATCC 6538P), Staphylococcus aureus (ATCC 6538) and Klebsiella pneumonia (ATCC 10031). The EAQ and theviridoside were tested by carrageenan â induced rats paw edema, in which presented 77.90% (p<0.05) of inhibition comparable with the control. The immunologic evaluation in vitro front of 4 cytokines (IL-4, IL-10, IFN-g and IL-2) and nitric oxide were tested in theviridoside and its periodate oxidation product. Any stimulation of those cytokines werenât observed in both substances, by linphoids cell

ASSUNTO(S)

lippia alba, verbenaceae, iridoids glucoside, chemotype lippia alba, verbenaceae, iridÃides glicosilados, quimiotipos farmacia

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