Iron-regulated outer membrane protein of Bacteroides fragilis involved in heme uptake.

AUTOR(ES)

Otto, B R

RESUMO

Under iron starvation, Bacteroides fragilis expresses various iron-regulated outer membrane proteins. In this study, a deferrated minimal medium was used in growth experiments, and the role of one of these iron-regulated outer membrane proteins (a 44-kDa protein) in an iron uptake mechanism which acquires iron from heme compounds was elucidated. When a specific 44-kDa protein antiserum was used in a medium with heme as the only iron source, growth inhibition was observed. These results demonstrate that the 44-kDa outer membrane protein plays an important role in the uptake of heme in B. fragilis.

Documentos Relacionados

• Iron-repressible outer membrane proteins of Helicobacter pylori involved in heme uptake.
• Vibrio cholerae expresses iron-regulated outer membrane proteins in vivo.
• Molecular characterization of the 98-kilodalton iron-regulated outer membrane protein of Neisseria meningitidis.
• Identification of an iron-regulated outer membrane protein of Neisseria meningitidis involved in the utilization of hemoglobin complexed to haptoglobin.
• Essential Role of the Iron-Regulated Outer Membrane Receptor FauA in Alcaligin Siderophore-Mediated Iron Uptake in Bordetella Species