Isolation and characterization of simian virus 40 early region deletion mutants.
AUTOR(ES)
Sompayrac, L M
RESUMO
We constructed a tsB4/dl884 double-mutant helper virus and used it to isolate two simian virus 40 early region deletion mutants that lack about half of the DNA sequences normally used to encode the large tumor antigen (T). Both mutants make a normal-sized small t antigen, but neither mutant can replicate its DNA in the absence of a T+ helper.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=256124Documentos Relacionados
- Viable deletion mutants in the simian virus 40 early region.
- Construction and Characterization of Viable Deletion Mutants of Simian Virus 40 Lacking Sequences near the 3′ End of the Early Region
- A rapid enzymatic DNA sequencing technique: determination of sequence alterations in early simian virus 40 temperature sensitive and deletion mutants.
- Biochemical activities of T-antigen proteins encoded by simian virus 40 A gene deletion mutants.
- DNA sequences of polyoma virus early deletion mutants.