Isolation and characterization of the alpha platelet-derived growth factor receptor from rat olfactory epithelium.
AUTOR(ES)
Lee, K H
RESUMO
We have cloned and characterized a new member of the receptor tyrosine kinase family. The cDNA clone, isolated from a rat olfactory cDNA library, has considerable homology to the family of receptors that includes the colony-stimulating factor 1 receptor, the c-kit proto-oncogene, and the platelet-derived growth factor (PDGF) receptors. Analysis of DNA sequence homology, ligand-binding, and ligand-stimulated phosphorylation data suggests that this clone encodes the rat PDGF-A/B or alpha-receptor. Comparison of its sequence to those of other receptors allows us to postulate a mechanism for receptor dimerization and activation. The expression of the rat alpha-PDGF receptor in nonneuronal cells of the olfactory epithelium and in the olfactory bulb is consistent with a role for PDGF in glial cell generation.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=360571Documentos Relacionados
- Platelet-derived growth factor alpha receptor gene expression: isolation and characterization of the promoter and upstream regulatory elements.
- Evolutionary Divergence of Platelet-Derived Growth Factor Alpha Receptor Signaling Mechanisms
- Retinoic acid promotes transcription of the platelet-derived growth factor alpha-receptor gene.
- Platelet-derived growth factor: purification and partial characterization.
- Biosynthesis and intracellular transport of the receptor for platelet-derived growth factor.
