Isolation and characterization of the opioid peptides from rat pituitary: beta-lipotropin.

AUTOR(ES)

Rubinstein, M

RESUMO

Rat beta-lipotropin was isolated from 40 anterior pituitaries using high efficiency chromatography columns and sensitive fluorometric methods. The beta-lipotropin was characterized as to molecular weight, amino acid composition, and generation of opioid activity by trypsinization. Other opioid peptides, as well as a precursor to opioid peptides with a molecular weight larger than that of beta-lipotropin, were observed in this tissue.

Documentos Relacionados

• Isolation and characterization of the opioid peptides from rat pituitary: beta-endorphin.
• Opioid activity of a peptide, beta-lipotropin-(61-91), derived from beta-lipotropin.
• Total synthesis of human beta-lipotropin.
• beta-Lipotropin is the major opioid-like peptide of human pituitary and rat pars distalis: lack of significant beta-endorphin.
• Secretory granules of an anterior pituitary cell line, AtT-20, contain only mature forms of corticotropin and beta-lipotropin.