Isolation, chemical structure, acute toxicity, and some physicochemical properties of territrem B' from Aspergillus terreus.
AUTOR(ES)
Peng, F C
RESUMO
We have isolated a metabolite of territrem, designated territrem B', from the chloroform extract of a rice culture of Aspergillus terreus 23-1 by using the same isolation procedure as that for territrems A, B, and C. The present isolation procedure gave about 10 mg of territrem B' from 4 kg of rice culture per batch. Analysis of the high-resolution mass spectrum showed that the molecular composition of territrem B' is C29H34O10 (found, 542.2167; required, 542.200). Some results of physicochemical and acute tests are presented in this paper. Single-crystal X-ray diffractometry of territrem B' indicated that the three-dimensional structure of territrem B' has not changed significantly from that of territrem B except for the insertion of one oxygen atom into territrem B to make an additional pyron ring in the E ring. The tremorgenic activity of territrem B' is greatly reduced as tested by intraperitoneal injection in mice.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=373580Documentos Relacionados
- Isolation, chemical structure, acute toxicity, and some physicochemical properties of territrem C from Aspergillus terreus.
- Itaconate biosynthesis in Aspergillus terreus.
- Territrems, tremorgenic mycotoxins of Aspergillus terreus.
- Structure, biosynthesis, and physicochemical properties of archaebacterial lipids.
- Structure, Biosynthesis, and Physicochemical Properties of Archaebacterial Lipids
