Isolation of Drosophila genes encoding G protein-coupled receptor kinases.
AUTOR(ES)
Cassill, J A
RESUMO
G protein-coupled receptors are regulated via phosphorylation by a variety of protein kinases. Recently, termination of the active state of two such receptors, the beta-adrenergic receptor and rhodopsin, has been shown to be mediated by agonist- or light-dependent phosphorylation of the receptor by members of a family of protein-serine/threonine kinases (here referred to as G protein-coupled receptor kinases). We now report the isolation of a family of genes encoding a set of Drosophila protein kinases that appear to code for G protein-coupled receptor kinases. These proteins share a high degree of sequence homology with the bovine beta-adrenergic receptor kinase. The presence of a conserved family of G protein-coupled receptor kinases in vertebrates and invertebrates points to the central role of these kinases in signal transduction cascades.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=53074Documentos Relacionados
- Increased pressure on G protein-coupled receptor kinases.
- Receptor and Gβγ isoform-specific interactions with G protein-coupled receptor kinases
- Phosphorylation-independent inhibition of parathyroid hormone receptor signaling by G protein-coupled receptor kinases
- G Protein-Coupled Receptor Genes in the FANTOM2 Database
- Cytomegalovirus homologs of cellular G protein-coupled receptor genes are transcribed.
