Joint estimation of copy number variation and reference intensities on multiple DNA arrays using GADA

AUTOR(ES)

Pique-Regi, Roger

FONTE

Oxford University Press

RESUMO

Motivation: The complexity of a large number of recently discovered copy number polymorphisms is much higher than initially thought, thus making it more difficult to detect them in the presence of significant measurement noise. In this scenario, separate normalization and segmentation is prone to lead to many false detections of changes in copy number. New approaches capable of jointly modeling the copy number and the non-copy number (noise) hybridization effects across multiple samples will potentially lead to more accurate results.

Documentos Relacionados

• Ribosomal DNA and Stellate gene copy number variation on the Y chromosome of Drosophila melanogaster.
• Detection of novel copy number variants in uterine leiomyomas using high-resolution SNP arrays
• Copy number variation has little impact on bead-array-based measures of DNA methylation
• High-Resolution Analysis of DNA Copy Number Using Oligonucleotide Microarrays
• MSX2 copy number increase and craniosynostosis: copy number variation detected by array comparative genomic hybridization