Kinetic diagram and free energy diagram for kinesin in microtubule-related motility.

AUTOR(ES)

Hill, T L

RESUMO

The theoretical formalism that shows how biochemistry (ATPase activity) is related to mechanics in muscle contraction can be extended to the role of kinesin in microtubule-related motility. The main features added are the freedom of kinesin molecules to come and go from the motility complex and the small number of operative kinesin molecules in some systems. The starting points for this kind of approach are the kinetic diagram of biochemical states and the corresponding free energy diagram for these states. These topics are introduced and discussed here in relation to those systems that are presumed to use kinesin.

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