Kinetics, distribution, and sites of destruction of indium-111 oxine labelled red cells in haemolytic anaemia.
AUTOR(ES)
Heyns, A D
RESUMO
The survival of red cells labelled with indium-111 oxine in the circulation was determined. In vivo distribution at equilibrium and sites of deposition at the T50In--that is, the half life of labelled red cells--were quantitated with a scintillation camera and computer assisted image analysis. Although the rate of elution. Of 111In from the red cells was higher than that of chromium-51-disodium chromate, estimates of T50In and T50Cr corresponded reasonably well and were shortened in haemolytic anaemia. In normal subjects red cells were sequestered mainly in the liver and spleen. In five patients with different types of haemolytic anaemia two distinct patterns of red cell sequestration could be recognised: mainly splenic sequestration, and destruction of red cells in the liver, spleen, and the bone marrow. These patterns were expected for the particular disease studied.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=499090Documentos Relacionados
- Detection of left atrial thrombi in man using indium-111 labelled autologous platelets.
- 111 Indium labelling of red cells: its clinical use in haemolytic anaemias.
- EDTA dependent red cell neutrophil rosetting in autoimmune haemolytic anaemia.
- Indium-111 labelled granulocyte scanning to detect inflammation in the lungs of patients with chronic sputum expectoration.
- Intrathoracic mycotic aneurysm detected by indium-111 labelled autologous neutrophils with single photon emission computed tomography.