Lack of evidence for a saturable tetracycline transport system in Staphylococcus aureus.
AUTOR(ES)
Chopra, I
RESUMO
Previous studies on tetracycline transport into Staphylococcus aureus identified a high-affinity, saturable uptake system for the antibiotic (Km, 4.76 microM) (B.L. Hutchings, Biochim. Biophys. Acta 174:734-738, 1969). However, the earlier results could not be confirmed using conditions that permitted energy-dependent, concentrative uptake of tetracycline. Kinetic artifacts introduced by inappropriate washing procedures may explain the previous results.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=245447Documentos Relacionados
- Lack of evidence for mutation to erythromycin resistance in clinical strains of Staphylococcus aureus.
- Identification of a high-affinity glycine betaine transport system in Staphylococcus aureus.
- Lack of reproducibility of macrodilution MBCs for Staphylococcus aureus.
- Cleavage maps of a tetracycline plasmid from Staphylococcus aureus.
- Carbohydrate transport in Staphylococcus aureus. V. The accumulation of phosphorylated carbohydrate derivatives, and evidence for a new enzyme-splitting lactose phosphate.
