Leptin Modulates Neutrophil Phagocytosis of Klebsiella pneumoniae
AUTOR(ES)
Moore, Sharlene I.
FONTE
American Society for Microbiology
RESUMO
Leptin is a pleiotropic hormone-cytokine known to regulate energy homeostasis and immune function. Neutrophils from leptin-deficient mice exhibited impaired phagocytosis of Klebsiella pneumoniae opsonized with serum containing complement and reduced CD11b expression that could be restored with exogenous leptin. These results suggest that leptin is required for normal neutrophil complement-mediated phagocytosis of bacteria.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=161963Documentos Relacionados
- Leukotriene B4 Augments Neutrophil Phagocytosis of Klebsiella pneumoniae
- 5-Lipoxygenase Reaction Products Modulate Alveolar Macrophage Phagocytosis of Klebsiella pneumoniae
- Relationships among capsular structure, phagocytosis, and mouse virulence in Klebsiella pneumoniae.
- Impairment of phagocytosis by the Klebsiella pneumoniae mannose-inhibitable adhesin-T7 receptor.
- Relationships between phagocytosis, mucoid phenotype, and genetic characteristics of Klebsiella pneumoniae clinical isolates
