Leptospires Are Killed In Vitro by Both Oxygen-Dependent and -Independent Reactions
AUTOR(ES)
Murgia, Rossella
FONTE
American Society for Microbiology
RESUMO
This study reports for the first time that leptospires are killed by H2O2 and by low-molecular-weight primary granule components, which are agents normally released by neutrophils upon stimulation. Although both pathogenic and nonpathogenic strains were sensitive to H2O2-mediated killing, nonpathogenic organisms were found to be more susceptible. In addition, the killing of leptospires by H2O2 was found to be independent of the presence of the neutrophil primary granule component myeloperoxidase and therefore not a consequence of halogenation reactions. We have also determined that leptospires are significantly sensitive only to primary granule components and, among those, to proteins and/or peptides of less than 30 kDa.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=133083Documentos Relacionados
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