Linezolid Penetration into Bone and Joint Tissues Infected with Methicillin-Resistant Staphylococci
AUTOR(ES)
Kutscha-Lissberg, Friedrich
FONTE
American Society for Microbiology
RESUMO
Penetration of linezolid into bone and joint tissues was studied by high-performance liquid chromatography in 13 patients suffering from implant-associated infections with methicillin-resistant staphylococci. Mean concentrations of linezolid in infected tissues were greater than 10 mg/liter in a sampling time range of 35 to 124 min after administration of the preoperative dose, except in bone specimens, where they reached 3.9 ± 2.0 mg/liter.
