Linkage disequilibrium and recombination make a telomeric site for the Huntington's disease gene unlikely.
AUTOR(ES)
Barron, L
RESUMO
In a Scottish family in which Huntington's disease (HD) was segregating, recombination was observed between the D4S115/S111 and D4S43/S95 loci, with the HD gene associated with the more proximal D4S43/S95 locus. Analysis of linkage disequilibrium in Scottish families showed significant non-random association between the HD gene and alleles at the D4S95 and D4S98 loci. This adds to previous evidence that the HD locus is not sited at the telomere of chromosome 4.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1016979Documentos Relacionados
- Linkage disequilibrium in Huntington's disease: an improved localisation for the gene.
- Predictive testing for Huntington's disease: after the gene. The United Kingdom Huntington's Disease Prediction Consortium.
- Considerations in using linkage analysis as a presymptomatic test for Huntington's disease.
- Predictive testing for Huntington's disease: protocol of the UK Huntington's Prediction Consortium.
- A specific mutation for Huntington's disease.
