Lipid Inclusions in L Cells Associated with Venezuelan Equine Encephalomyelitis Virus Infection

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Hardy, Frank M. (Fort Detrick, Frederick, Md.), and David Arbiter. Lipid inclusions in L cells associated with Venezuelan equine encephalomyelitis virus infection. J. Bacteriol. 89:1101–1103. 1965.—Venezuelan equine encephalomyelitis (VEE) virus has been shown to induce changes of lipid components within the L cell. Lipid inclusions in the form of dark granular bodies were observed in the L cell after aqueous osmium tetroxide fixation and Sudan black staining. Microscopic examination of cells as early as 8 hr after infection with VEE virus showed an increase in the concentration of these inclusions within the cytoplasm. According to various lipid solubility criteria, the inclusions were considered a combination of heterogeneous phospholipids.

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