Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancer
AUTOR(ES)
Ding, Xian-Zhong
FONTE
BioMed Central
RESUMO
The essential fatty acids, linoleic acid and arachidonic acid play an important role in pancreatic cancer development and progression. These fatty acids are metabolized to eicosanoids by cyclooxygenases and lipoxygenases. Abnormal expression and activities of both cyclooxygenases and lipoxygenases have been reported in pancreatic cancer. In this article, we aim to provide a brief summary of (1) our understanding of the roles of these enzymes in pancreatic cancer tumorigenesis and progression; and (2) the potential of using cyclooxygenase and lipoxygenase inhibitors for pancreatic cancer treatment and prevention.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=149414Documentos Relacionados
- Monogenic hypercholesterolemia: new insights in pathogenesis and treatment
- New molecular aspects in pathogenesis and progression of pancreatic cancer
- Phyto-oestrogens and breast cancer chemoprevention
- Renal involvement in leptospirosis: new insights into pathophysiology and treatment
- Regulation of Cerebral Blood Flow and Metabolism: Neurosurgical Treatment of Epilepsy: Rehabilitation in Neurosurgery. (Advances in Neurosurgery Vol 15.)
