Local anesthetics block transient expression of inducible functions for transformation in Streptococcus sanguis.
AUTOR(ES)
Raina, J L
RESUMO
Procaine and tetracaine reversibly inhibit transformation by preventing the transient expression of competence-specific, inducible functions, which are usually triggered in response to cellular stimulation with competence protein. Affinity studies with 14C-labeled procaine showed that the anesthetic bound to cell surface macromolecules specifically in the initiation phases of competence-specific events and blocked transfer of information imparted by cellular membrane receptor(s) upon interaction with competence protein.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=215107Documentos Relacionados
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