Local cerebral glucose utilisation in chronic alcoholics: a positron tomographic study.

AUTOR(ES)

Samson, Y

RESUMO

Using positron tomography, a study of regional cerebral glucose utilisation was performed prospectively in a highly selected group of six neurologically unaffected primary chronic alcoholics. In this group, neuropsychological, behavioural and CT scan anomalies were comparable with those previously reported in more extensive studies. With respect to age-matched control values, cerebral metabolic rate was not significantly modified in the selected cortical, subcortical and cerebellar regions of interest. However, the metabolic regional distribution index, which reflects the distribution pattern of glucose utilisation, was selectively and significantly decreased in the medio-frontal area, pointing to a limbic metabolic dysfunction apparently linked to chronic alcoholism.

Documentos Relacionados

• Pellagra among chronic alcoholics: clinical and pathological study of 20 necropsy cases.
• Muscle wasting in chronic alcoholics: comparative histochemical and biochemical studies.
• Regional cerebral glucose metabolism in late-life depression and Alzheimer disease: a preliminary positron emission tomography study.
• Local cerebral glucose utilisation in treated and untreated patients with Parkinson's disease.
• Operational criteria for the classification of chronic alcoholics: identification of Wernicke's encephalopathy.