Local control of neurite development by nerve growth factor

AUTOR(ES)

Campenot, Robert B.

RESUMO

A three-chamber culture system was devised in which neurites growing from small clusters of somas of sympathetic neurons penetrated a virtually fluid-impermeable barrier; thus the local fluid environment of the distal portions of the neurites could be controlled independently of the local fluid environment of the somas and proximal portions of the neurites. Neurites regularly penetrated the barriers if a high concentration of nerve growth factor was present on both sides, but never penetrated into chambers to which no nerve growth factor had been added.

Documentos Relacionados

• An effect of nerve growth factor on parasympathetic neurite outgrowth.
• Liquiritin potentiate neurite outgrowth induced by nerve growth factor in PC12 cells
• Induction of neurite outgrowth by v-src mimics critical aspects of nerve growth factor-induced differentiation.
• Evidence for RNA synthesis-dependent and -independent pathways in stimulation of neurite outgrowth by nerve growth factor
• Identification of a peripheral nerve neurite growth-promoting activity by development and use of an in vitro bioassay.