Longitudinal study of transmission, diversity and stability of mutans streptococci genotypes in Brazilian families / Estudo longitudinal sobre similaridade, transmissão, e estabilidade de colonização de Estreptococcus mutans em famílias brasileiras

AUTOR(ES)
DATA DE PUBLICAÇÃO

2007

RESUMO

The objective of this study was to investigate in a longitudinal study the transmission of Streptococcus mutans in Brazilian families of a low socioeconomic status. An important entry criterion for the study was to include all members of a household in the study. The study cohort was comprised of 14 mothers, fathers and children and 8 grandmothers. Saliva samples were collected for S. mutans analysis in 4 visits during 22 months. Only eight children were positive for S. mutans by employing DNA-DNA hybridization that was also applied to household members. A total of 506 isolates of S. mutans were genotyped by AP-PCR with the primer OPA-02. Twenty genotypes were detected in 8 families ranging from 1 to 5 in the adults and 1-2 in the children. All mothers and some fathers and grandmothers shared similar genotypes with the children. In all families homologous genotypes were encountered among adults. Some genotypes were stable, and others were lost although sharing a similar environment may favor additional transmission episodes. Three children developed decay during the study period. The fact that children shared genotypes from all household members suggest that reevaluation of preventive methods aimed at suppressing S. mutans infections should include additional family members and not only the mothers.

ASSUNTO(S)

ap-pcr streptococcus mutansm transmissão agentes antimicrobianos

ACESSO AO ARTIGO

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