Loss of virulence associated with absence of flagellum in an isogenic mutant of Pseudomonas aeruginosa in the burned-mouse model.
AUTOR(ES)
Montie, T C
RESUMO
To test the importance of flagella as a virulence factor, virulent strain Pseudomonas aeruginosa M-2 was mutagenized, and a Fla mutant was isolated. An M-2 Fla spontaneous motile revertant was isolated from M-2 Fla. The three strains were biochemically and morphologically identical. Assay of Fla in the burned-mouse model showed a severe loss of virulence. The Fla revertant was fully virulent. The importance of P. aeruginosa motility (flagella) for virulence in burns infections is indicated.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=347889Documentos Relacionados
- Salmonella typhimurium virulence in a burned-mouse model.
- Avirulence of a Pseudomonas aeruginosa algC mutant in a burned-mouse model of infection.
- Passive protection against Pseudomonas aeruginosa infection in an experimental leukopenic mouse model.
- Virulence of different Pseudomonas species in a burned mouse model: tissue colonization by Pseudomonas cepacia.
- An Adenylate Cyclase-Controlled Signaling Network Regulates Pseudomonas aeruginosa Virulence in a Mouse Model of Acute Pneumonia
