Low-level resistance to the cephalosporin 3'-quinolone ester Ro 23-9424 in Escherichia coli.
AUTOR(ES)
Chapman, J S
RESUMO
Four spontaneous, single-step mutants of Escherichia coli K-12 resistant to low levels of the cephalosporin 3'-quinolone ester Ro 23-9424 were isolated at a frequency of 10(-10) to 10(-11) mutants per CFU plated. The mutants were cross-resistant to both cephalosporin (cefotaxime) and quinolone (fleroxacin) components. Accordingly, they had altered porins and replicative DNA biosynthesis resistant to fleroxacin. There was no increase in beta-lactamase activity when tested with nitrocephin, and the penicillin-binding protein profiles were normal.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=162583Documentos Relacionados
- Escherichia coli resistant to cephalosporins and quinolones is still susceptible to the cephalosporin-quinolone ester Ro 23-9424.
- In vitro activity of Ro 23-9424 against clinical isolates of Legionella species.
- Mode of action of the dual-action cephalosporin Ro 23-9424.
- Pharmacokinetics of Ro 23-9424, a dual-action cephalosporin, in animals.
- Mechanisms of action of cephalosporin 3'-quinolone esters, carbamates, and tertiary amines in Escherichia coli.