LY146032 compared with penicillin G in experimental aortic valve endocarditis caused by group G streptococci.
AUTOR(ES)
Bayer, A S
RESUMO
Rabbits with group G streptococcal aortic endocarditis received no therapy (controls); repeated doses of procaine penicillin G, 300 mg/kg (body weight) per day, administered intramuscularly; or LY146032, a new peptolide antibiotic, 20 mg/kg per day, administered intravenously. Penicillin G and LY146032 reduced mean intravegetation group G streptococcal densities significantly below those observed in controls at both day 3 and day 6 of therapy. Penicillin G effected a more rapid clearance of intravegetation streptococci than LY146032 by day 3, but not by day 6, of therapy.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=172116Documentos Relacionados
- Daptomycin (LY146032) for prevention and treatment of experimental aortic valve endocarditis in rabbits.
- Antimicrobial therapy of experimental endocarditis caused by nutritionally variant viridans group streptococci.
- In vitro activity of LY146032 against staphylococci, streptococci, and enterococci.
- Comparison of cefazolin, cefamandole, vancomycin, and LY146032 for prophylaxis of experimental Staphylococcus epidermidis endocarditis.
- Parenteral sparfloxacin compared with ceftriaxone in treatment of experimental endocarditis due to penicillin-susceptible and -resistant streptococci.
