Lycopene and resveratrol pretreatment did not interfere with the liver of hepatectomized rats

AUTOR(ES)

Barros, Pedro Paulo, Gonçalves, Gisele Mara Silva, Silva, Gustavo Henrique da, Bastos, Maria Clara Villaça Dias, Ramos, Loren Nogaroto, Fernandes, Marilia Marinello

FONTE

Acta Cir. Bras.

DATA DE PUBLICAÇÃO

2017-03

RESUMO

Abstract Purpose: To investigate the effects of lycopene and resveratrol pretreatment on hepatic hyperplasia in partially hepatectomized rats. Methods: The lycopene group and the resveratrol group received 40 mg/kg/day of lycopene or resveratrol, respectively (dissolved in olive oil or in saline solution, respectively) and administered via a gastric tube for 30 days. The partially hepatectomzed (PH) control groups received saline or olive oil via a gastric tube for 30 days, respectively, and the normal control group received no treatment. Liver tissue and intracardiac blood samples were obtained 24, 36 or 48 h after PH. Results: No areas of fibrosis were detected. No significant changes in mitotic index, in the number of apoptosis events or in aspartate aminotransferase and alanine aminotransferase levels were observed. Conclusions: Lycopene and resveratrol pretreatment did not interfere on hepatic hyperplasia in partially hepatectomized rats.

Documentos Relacionados

• Pretreatment of hepatetctomized rats with Coleus forskohlii did not interfere with the course of hepatic hyperplasia
• Bile secretion and liver regeneration in partially hepatectomized rats.
• Effect of cyclosporine on liver regeneration in partial hepatectomized rats
• The use of light-emitting diodes to stimulate mitochondrial function and liver regeneration of partially hepatectomized rats
• Stimulation of DNA and Protein Synthesis in Fetal-Rat Liver Cells by Serum from Partially Hepatectomized Rats