Lymphocyte-macrophage co-operation during induction of T-suppressor cell activity in rats with adjuvant arthritis.
AUTOR(ES)
Binderup, L
RESUMO
The role of macrophages and of macrophage-lymphocyte co-operation in the induction of T-suppressor cell activity in rats with adjuvant arthritis was investigated. Macrophages from arthritic rats had no direct effect on the induction of T-suppressor cells, but, in the presence of arthritic rats' lymphocytes or supernatants from such lymphocytes, macrophages inhibited the induction of T-suppressor cell activity. Addition of indomethacin during the induction of T-suppressor cells reduced the inhibitory effects, suggesting that prostaglandins released from lymphocyte-activated macrophages might be involved in the defective induction of T-suppressor cell activity in rats with adjuvant arthritis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1001331Documentos Relacionados
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