Macrolide antibiotics protect against endotoxin-induced vascular leakage and neutrophil accumulation in rat trachea.
AUTOR(ES)
Tamaoki, J
RESUMO
We studied the effects of macrolides on lipopolysaccharide (LPS)-induced airway inflammation in the rat tracheal mucosa. Erythromycin and roxithromycin dose dependently inhibited microvascular leakage and neutrophil recruitment induced by LPS. This inhibitory action on vascular permeability was abolished by neutrophil depletion.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=284605Documentos Relacionados
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