Maintenance of pluripotency in mouse embryonic stem cells persistently infected with murine coronavirus.
AUTOR(ES)
Okumura, A
RESUMO
A persistently coronavirus-infected embryonic stem (ES) cell line A3/MHV was established by infecting an ES cell line, A3-1, with mouse hepatitis virus type-2. Although almost all A3/MHV cells were found infected, both A3/MHV and A3-1 cells expressed comparable levels of cell surface differentiation markers. In addition, A3/MHV cells retained the ability to form embryoid bodies. These results suggest that persistent coronavirus infection does not affect the differentiation of ES cells.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=190306Documentos Relacionados
- Maintenance of an extrachromosomal plasmid vector in mouse embryonic stem cells.
- The murine coronavirus mouse hepatitis virus strain A59 from persistently infected murine cells exhibits an extended host range.
- Embryonic stem cell virus, a recombinant murine retrovirus with expression in embryonic stem cells.
- Telomere Maintenance in Telomerase-Deficient Mouse Embryonic Stem Cells: Characterization of an Amplified Telomeric DNA
- The N-Terminal Region of the Murine Coronavirus Spike Glycoprotein Is Associated with the Extended Host Range of Viruses from Persistently Infected Murine Cells
