Mapping of cellular protein-binding sites on the products of early-region 1A of human adenovirus type 5.

AUTOR(ES)

Egan, C

RESUMO

The binding sites for the 300-, 107-, and 105-kilodalton cellular proteins which associate with human adenovirus type 5 E1A products were studied with E1A deletion mutants. All appeared to bind to the amino-terminal half of E1A products in regions necessary for oncogenic transformation. These results suggest that these cellular species may be important for the biological activity of E1A products.

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