Marked Enhancement of the Antigen-Specific Immune Response by Combining Plasmid DNA-Based Immunization with a Schiff Base-Forming Drug
AUTOR(ES)
Charo, Jehad
FONTE
American Society for Microbiology
RESUMO
Although plasmid DNA (pDNA)-based immunization has proven efficacy, the level of immune responses that is achieved by this route of vaccination is often lower than that induced by traditional vaccines, especially for primates and humans. We report here a simple and potent method to enhance pDNA-based vaccination by using two different plasmids encoding viral or bacterial antigens. This method is based on coadministration of low concentrations of a recently described immunopotentiating, Schiff base-forming drug called tucaresol which has led to significant augmentation of antigen-specific humoral and cellular immune responses. Our data suggest that enhancement of the immune response with tucaresol might provide a powerful tool for the further development of pDNA-based immunization for humans.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=133029Documentos Relacionados
- Protective Efficacy of a DNA Influenza Virus Vaccine Is Markedly Increased by the Coadministration of a Schiff Base-Forming Drug
- Altering the Cellular Location of an Antigen Expressed by a DNA-Based Vaccine Modulates the Immune Response
- Antigen-specific drug-targeting used to manipulate an immune response in vivo.
- Immunization of the Female Genital Tract with a DNA-Based Vaccine
- Enhancement of Antigen-Specific Suppression by Muramyl Dipeptide