Mass Spectrometry Analysis of Protonated Marine Natural Product Seriniquinone

AUTOR(ES)

Silva, Rodrigo M. da, Guaratini, Thais, Jimenez, Paula C., Fenical, William, Costa-Lotufo, Letícia V., Vessecchi, Ricardo, Lopes, Norberto P.

FONTE

J. Braz. Chem. Soc.

DATA DE PUBLICAÇÃO

2018-05

RESUMO

Seriniquinone is a natural quinone isolated from a rare marine bacterium of the genus Serinicoccus. This secondary metabolite has been shown to have anticancer properties, which has raised attention of the scientific community. In this short report, we present the first investigation of the gas-phase chemistry fragmentation reactions of seriniquinone in electrospray ionization tandem mass spectrometry (ESI-MS/MS), to be further applied in pharmacokinetics and metabolism studies. All the proposals herein were supported by computational chemistry.

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