Maternal Repression of the P Element Promoter in the Germline of Drosophila Melanogaster: A Model for the P Cytotype
AUTOR(ES)
Lemaitre, B.
RESUMO
The transposition of P elements in Drosophila melanogaster is regulated by products encoded by the P elements themselves. The P cytotype, which represses transposition and associated phenomena, exhibits both a maternal effect and maternal inheritance. The genetic and molecular mechanisms of this regulation are complex and not yet fully understood. In a previous study, using P-lacZ fusion genes, we have shown that P element regulatory products were able to inhibit the activity of the P promoter in somatic tissues. However, the repression observed did not exhibit the maternal effect characteristic of the P cytotype. With a similar approach, we have assayed in vivo the effect of P element regulatory products in the germline. We show that the P cytotype is able to repress the P promoter in the germline as well as in the soma. Furthermore, this repression exhibits a maternal effect restricted to the germline. On the basis of these new observations, we propose a model for the mechanism of P cytotype repression and its maternal inheritance.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1205614Documentos Relacionados
- Cytotype Control of Drosophila Melanogaster P Element Transposition: Genomic Position Determines Maternal Repression
- Transposase titration in Drosophila melanogaster: a model of cytotype in the P-M system of hybrid dysgenesis.
- Repressor of P elements in Drosophila melanogaster: Cytotype determination by a defective P element carrying only open reading frames 0 through 2
- P-Element-Induced Recombination in Drosophila Melanogaster: Hybrid Element Insertion
- Hybrid Dysgenesis in DROSOPHILA MELANOGASTER: The Genetics of Cytotype Determination in a Neutral Strain