Maximal binding levels of an H1 histone gene-specific factor in S-phase correlate with maximal H1 gene transcription.
AUTOR(ES)
Dalton, S
RESUMO
Levels of trans-acting factor (H1-SF) binding to the histone H1 gene-specific motif (5'-AAACACA-3' [L. S. Coles and J. R. E. Wells, Nucleic Acids Res. 13:585-594, 1985]) increase 12-fold from G1 to S-phase in synchronized cells and decrease again in G2 phase of the cell cycle. Since the H1 element is required for S-phase expression of H1 genes (S. Dalton and J. R. E. Wells, EMBO J. 7:49-56, 1988), it is likely that the increased levels of H1-SF binding component play an important role in S-phase regulation of H1 gene transcription.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=365540Documentos Relacionados
- A gene-specific promoter element is required for optimal expression of the histone H1 gene in S-phase.
- An H1 histone gene-specific 5' element and evolution of H1 and H5 genes.
- Transcription of the histone H5 gene is not S-phase regulated.
- Transcription from the intron-containing chicken histone H2A.F gene is not S-phase regulated.
- Transforming growth factor beta 1 inhibition of p34cdc2 phosphorylation and histone H1 kinase activity is associated with G1/S-phase growth arrest.