Mechanism of poliovirus inactivation by ammonia.

AUTOR(ES)

Ward, R L

RESUMO

Poliovirus inactivation by ammonia causes a slight reduction in the sedimentation coefficients of viral particles, but has no detectable effect on either the electrophoretic pattern of viral capsid proteins or the isoelectric points of inactivated particles. These virions still attach to cells, but are unable to repress host translation or stimulate the synthesis of detectable amounts of viral RNA. Although ammonia has no detectable effect on naked poliovirus RNA, it causes cleavage of this RNA when still within viral particles. Therefore, the RNA genome appears to be the only component of poliovirus significantly affected by ammonia.

Documentos Relacionados

• Effect of heat on virus inactivation by ammonia.
• Mechanism of poliovirus inactivation by bromine chloride.
• Mechanism-Based Inactivation of Ammonia Monooxygenase in Nitrosomonas europaea by Allylsulfide
• Ureaplasmal epithelial lesions related to ammonia.
• Stability of oligodeoxynucleoside phosphorodithioates and phosphorothioates in aqueous ammonia.