Mechanism of virucidal activity of retinoids: protein removal from bacteriophage phi 6 envelope.
AUTOR(ES)
Reinhardt, A
RESUMO
The mechanism of the potent virucidal activity of retinol (vitamin A) and retinal (vitamin A aldehyde) was investigated for the interaction of these compounds with a model system enveloped virus, bacteriophage phi 6. The retinoids bind to and inactivate phi 6 without causing large-scale disruption of the virion. Inactivated virions have completely lost the ability to adsorb to host bacteria due to the loss of a viral envelope protein necessary for adsorption.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=283925Documentos Relacionados
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