Mechanisms of Internalization of Staphylococcus aureus by Cultured Human Osteoblasts
AUTOR(ES)
Jevon, Marc
FONTE
American Society for Microbiology
RESUMO
Staphylococcus aureus is an important bone pathogen, and evidence shows that this organism is internalized by chick osteoblasts. Here we report that S. aureus is internalized by human osteoblasts. Internalization was inhibited by monodansylcadaverine and cytochalasin D and to a lesser extent by ouabain, monensin, colchicine, and nocodazole. We propose that internalization occurs via a receptor-mediated pathway, requiring the participation of cytoskeletal elements, principally actin.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=116025Documentos Relacionados
- The σB Regulon Influences Internalization of Staphylococcus aureus by Osteoblasts
- Internalization of Staphylococcus aureus by Human Keratinocytes
- Staphylococcus aureus Fibronectin Binding Proteins Are Essential for Internalization by Osteoblasts but Do Not Account for Differences in Intracellular Levels of Bacteria
- Internalization of Staphylococcus aureus by Endothelial Cells Induces Apoptosis
- Internalization of Staphylococcus aureus by endothelial cells induces cytokine gene expression.