Mediadores de inflamação e pré-eclâmpsia: análise de polimorfismos de genes codificadores de IL1-R1, IL-12, IL-18, TLR-2 e TLR-4 / Inflammatory mediators and preeclampsia: analysis of IL-1R1, IL-12, IL-18, TLR-2 and TLR-4 gene polymorphisms.

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

29/04/2009

RESUMO

Problem: Intense maternal inflammatory response is a central event in the pathogenesis of preeclampsia (PE) Our aim was to assess a possible relation between pro-inflammatory mediators: IL-1R1, IL-12, IL-18, IL-18, TLR-2 and TLR-4 gene polymorphisms and PE. Method of Study: This case-control study included 109 patients with PE and 174 healthy women (controls). Genotyping were performed by PCR-ARMS or PCR-RFLP techniques. Data were analyzed by Students t or Fischers exact tests, and significance was set at p<0.05. Results: Genotypic and allelic distribution for all six polymorphisms was similar between the study and control groups (p=0.82 for IL-1R1, p=0.93 for IL-12, p=0.74 for IL-18 -137, p=0.22 for IL-18 -607, p=0.97 for TLR-2 and p=0.23 for TLR-4 gene polymorphisms). Conclusions: Our findings suggest that the analyzed pro-inflammatory gene polymorphisms are not associated with the occurrence of PE. Further studies have to be done to confirm these results.

ASSUNTO(S)

pré-eclâmpsia inflamação polimorfismos genéticos citocinas receptores tipo toll. ginecologia e obstetricia preeclampsia polymorphisms

ACESSO AO ARTIGO

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