Mesangial Function in Ureteral Obstruction in the Rat: BLOCKADE OF THE EFFERENT LIMB
AUTOR(ES)
Raij, Leopoldo
RESUMO
The kinetics for mesangial uptake and transport of radiolabeled aggregated human immunoglobulin (Ig)G (AHIgG125I) deviated markedly from normal in male Sprague-Dawley rats with ureteral obstruction. Four experimental groups, each containing 25 rats, were used: (a) bilateral ureteral ligation (BUL) with release of one ureter 24 h later; (b) unilateral ureteral ligation with release 24 h later [UUL(R)]; (c) unilateral ureteral ligation without release (unreleased) [UUL(U)]; (d) uremia-control, which consisted of rats with ligated left ureter and a severed right ureter. A similar number of sham-operated rats served as control for each group. AHIgG125I (45 mg/100 g body wt) was given intravenously 1 h after release of the ureteral obstruction (25 h after ureteral obstruction or sham surgery). Groups of five control and five experimental animals were sacrificed at 2, 4, 8, 16, and 24 h after injection.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=371265Documentos Relacionados
- Atorvastatin protects renal function in the rat with acute unilateral ureteral obstruction
- Deep nephron function after release of acute unilateral ureteral obstruction in the young rat.
- Effects of Acute Bilateral Ureteral Obstruction on Deep Nephron and Terminal Collecting Duct Function in the Young Rat
- The Renal Functional Defect of Postobstructive Nephropathy: THE EFFECTS OF BILATERAL URETERAL OBSTRUCTION IN THE RAT
- Adrenomedullary function in the neonatal rat: responses to acute hypoxia.