Metabolism of pyrimidine bases and nucleosides in Bacillus subtilis.
AUTOR(ES)
Rima, B K
RESUMO
In Bacillus subtilis, uracil (Ura), uridine (Urd), and deoxyuridine (dUrd) are metabolized through pathways similar to those of enteric bacteria. Ura is probably converted to uridine 5'-monophosphate by uridine 5'-monophosphate pyrophosphorylase. More than 95% of dUrd added to cultures is converted to Ura and deoxyribose-1-phosphate. Although dUrd kinase activity is detectable in vitro, this enzyme does not seem to play an important role in the metabolism of dUrd. The metabolism of cytosine (Cyt), cytidine (Cyd), and deoxycytidine (dCyd) in B. subtilis appears to be different from that in enteric bacteria. Cytosine cannot be used by Ura-requiring mutants as pyrimidine source. dCyd is deaminated by dCyd-Cyd deaminase or phosphorylated to dCyd nucleotides by dCyd kinase. Cyd is deaminated by dCyd-Cyd deaminase of phosphorylated by Cyd kinase. This Cyd kinase activity has never been reported for B. subtilis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=234978Documentos Relacionados
- Metabolism of pyrimidine bases and nucleosides in Neisseria meningitidis.
- Metabolism of pyrimidine bases and nucleosides in the coryneform bacteria Brevibacterium ammoniagenes and Micrococcus luteus.
- Effect of purine and pyrimidine limitations on RNA synthesis in Bacillus subtilis.
- Coordinate synthesis of the enzymes of pyrimidine biosynthesis in Bacillus subtilis.
- Identification of an intracellular pyrimidine-specific endoribonuclease from Bacillus subtilis.